MedPage Today: Blood Test Shows Promise as Colorectal Cancer Screen

‘Natural killer’ cells are more active in older women

By John Gever
Managing Editor, MedPage Today
May 25, 2016

A blood test that evaluates natural killer cell activity (NKA) showed high sensitivity and, consequently, high negative predictive value in screening patients at risk for colorectal cancer that could make it clinically useful if confirmed in further studies, researchers said here.

The quantitative ELISA test for low NKA, called NKvue and offered by one clinical lab in the U.S. and several in Canada, showed sensitivity of 85.7% and a negative predictive value of 99.3% in a trial conducted among patients at increased risk for colorectal cancer on the basis of positive fecal immunochemical test (FIT) results or other factors, said Gilles Jobin, MD, of the University of Montreal.

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