Product Information
- Product Type
- Recombinant Protein
- Expression System
- E.coli
- Domain
- 1-140aa
- UniProt No.
- P37840
- NCBI Accession No.
- NP_000336
- Alternative names
- SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body
Product Specification
- Molecular Weight
- 14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
- Concentration
- Reconstitute in sterile distilled water at a concentration of 1mg/ml or less.
- Formulation
- Lyophilized from a 0.2 um filtered in 20mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl, 1mM MgCl2
- Purity
- > 95% by SDS-PAGE
- Endotoxin
- < 1 EU per 1ug of protein (determined by LAL method)
- Tag
- Non-Tagged
- Applications
- SDS-PAGE
- Storage
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Data
SDS-PAGE
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Related Publications
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Rodriguez-Araujo G, et al. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. (Cell Mol Life Sci. 2013)
Kim JY, et al. Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway. (Neural Regen Res. 2013)
Kim HL, et al. The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity. (J Proteome Res. 2013)
Rodriguez-Araujo G, et al. Low alpha-synuclein levels in the blood are associated with insulin resistance. (Sci Rep. 2015)
Takami Y, et al. Novel pathophysiological roles of α-synuclein in age-related vascular endothelial dysfunction. (FASEB J. 2022)
Lu J, et al. A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinsons disease. (J Neuroinflammation. 2022)
Wang D, et al. Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming. (Acta Pharm Sin B. 2023)
Lee J, et al. Targeted degradation of ⍺-synuclein aggregates in Parkinsons disease using the AUTOTAC technology. (Mol Neurodegener. 2023)
Note: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.