Recombinant human alpha-Synuclein protein

Cat No.
SNA2001

Size

QTY

List Price

20ug

USD 55


100ug

USD 160

1mg

USD 480

USD 0



Product Information

Product Type
Recombinant Protein
Expression System
E.coli
Domain
1-140aa
UniProt No.
P37840
NCBI Accession No.
NP_000336.1
Alternative names
SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha,

Product Specification

Molecular Weight
14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Concentration
1mg/ml (determined by BCA assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
Purity
> 95% by SDS-PAGE
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Tag
Non-Tagged
Applications
SDS-PAGE
Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Data

SDS-PAGE

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain. ..

Related Publications

    Sung JY, et al. Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. (J Biol Chem. 2005)
    Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006)

    Kim EJ, et al. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. (J Biol Chem. 2006 Nov)

    Lee HJ, et al. Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. (Int J Biochem Cell Biol. 2008)

    Lee HJ, et al. Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. (Biochem Biophys Res Commun. 2008)

    Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008)

    Lee HJ, et al. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. (J Biol Chem. 2010)

    Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010)

    Lee HJ, et al. Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. (J Neurosci Methods. 2011)

    Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012)

    Rodriguez-Araujo G, et al. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. (Cell Mol Life Sci. 2013)

    Kim JY, et al. Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway. (Neural Regen Res. 2013)

    Rodriguez-Araujo G, et al. Low alpha-synuclein levels in the blood are associated with insulin resistance. (Sci Rep. 2015)

Note: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.